Metabolic dysfunction-associated steatotic liver disease (MASLD), previously referred to under the umbrella of non-alcoholic fatty liver disease (NAFLD), is now recognized as the most prevalent chronic liver disease condition globally, closely linked to the rising rates of obesity [1, 2]
Texas A&M University, College Station
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In the kidney, GLP-1RAs directly induce natriuresis and diuresis by acting on the proximal convoluted tubule (PCT) through inhibition of sodium-hydrogen exchanger 3 (NHE3)
(III)Potential Clinical Significance: Current interventions for gastrointestinal dysfunction primarily rely on dietary adjustments and probiotic supplementation, with a lack of targeted pharmacological options